How can optimal patient population be identified for trial recruitment and how can the population be retained, keeping dropouts to minimum. Less than 5% of Patients participate in Clinical Research, 48% of sites miss enrollment targets and 49% of trial participants drop out before study ends. The cost of conducting onsite clinical trials is estimated at $2.6 billion. Forty percent of study patients fail to adhere to study protocols after 150 days into the trial – suffering from temporary bouts of toxicity and introducing irregularities into the data being captured by clinicians. The significant portion of this cost occurs in on-site clinical trials. How do we optimize patient enrollment and reduce dropout rates?